Medico italiano trova cura per la sclerosi multipla?

[AlexGatti]

Possibile?

http://www.gizmag.com/ccsvi-multiple...zamboni/13447/

An Italian doctor has been getting dramatic results with a new type of treatment for Multiple Sclerosis, or MS, which affects up to 2.5 million people worldwide. In an initial study, Dr. Paolo Zamboni took 65 patients with relapsing-remitting MS, performed a simple operation to unblock restricted bloodflow out of the brain - and two years after the surgery, 73% of the patients had no symptoms. Dr. Zamboni's thinking could turn the current understanding of MS on its head, and offer many sufferers a complete cure.

Multiple sclerosis, or MS, has long been regarded as a life sentence of debilitating nerve degeneration. More common in females, the disease affects an estimated 2.5 million people around the world, causing physical and mental disabilities that can gradually destroy a patient's quality of life.

It's generally accepted that there's no cure for MS, only treatments that mitigate the symptoms - but a new way of looking at the disease has opened the door to a simple treatment that is causing radical improvements in a small sample of sufferers.

Italian Dr. Paolo Zamboni has put forward the idea that many types of MS are actually caused by a blockage of the pathways that remove excess iron from the brain - and by simply clearing out a couple of major veins to reopen the blood flow, the root cause of the disease can be eliminated.

Dr. Zamboni's revelations came as part of a very personal mission - to cure his wife as she began a downward spiral after diagnosis. Reading everything he could on the subject, Dr. Zamboni found a number of century-old sources citing excess iron as a possible cause of MS. It happened to dovetail with some research he had been doing previously on how a buildup of iron can damage blood vessels in the legs - could it be that a buildup of iron was somehow damaging blood vessels in the brain?

He immediately took to the ultrasound machine to see if the idea had any merit - and made a staggering discovery. More than 90% of people with MS have some sort of malformation or blockage in the veins that drain blood from the brain. Including, as it turned out, his wife.

He formed a hypothesis on how this could lead to MS: iron builds up in the brain, blocking and damaging these crucial blood vessels. As the vessels rupture, they allow both the iron itself, and immune cells from the bloodstream, to cross the blood-brain barrier into the cerebro-spinal fluid. Once the immune cells have direct access to the immune system, they begin to attack the myelin sheathing of the cerebral nerves - Multiple Sclerosis develops.

He named the problem Chronic Cerebro-Spinal Venous Insufficiency, or CCSVI.

Zamboni immediately scheduled his wife for a simple operation to unblock the veins - a catheter was threaded up through blood vessels in the groin area, all the way up to the effected area, and then a small balloon was inflated to clear out the blockage. It's a standard and relatively risk-free operation - and the results were immediate. In the three years since the surgery, Dr. Zamboni's wife has not had an attack.

Widening out his study, Dr. Zamboni then tried the same operation on a group of 65 MS-sufferers, identifying blood drainage blockages in the brain and unblocking them - and more than 73% of the patients are completely free of the symptoms of MS, two years after the operation.

In some cases, a balloon is not enough to fully open the vein channel, which collapses either as soon as the balloon is removed, or sometime later. In these cases, a metal stent can easily be used, which remains in place holding the vein open permanently.

Dr. Zamboni's lucky find is yet to be accepted by the medical community, which is traditionally slow to accept revolutionary ideas. Still, most agree that while further study needs to be undertaken before this is looked upon as a cure for MS, the results thus far have been very positive.

Naturally, support groups for MS sufferers are buzzing with the news that a simple operation could free patients from what they have always been told would be a lifelong affliction, and further studies are being undertaken by researchers around the world hoping to confirm the link between CCSVI and MS, and open the door for the treatment to become available for sufferers worldwide.

It's certainly a very exciting find for MS sufferers, as it represents a possible complete cure, as opposed to an ongoing treatment of symptoms. We wish Dr. Zamboni and the various teams looking further into this issue the best of luck.

[dantes76]

Originariamente inviato da AlexGatti

Possibile?

http://www.gizmag.com/ccsvi-multiple...zamboni/13447/

An Italian doctor has been getting dramatic results with a new type of treatment for Multiple Sclerosis, or MS, which affects up to 2.5 million people worldwide. In an initial study, Dr. Paolo Zamboni took 65 patients with relapsing-remitting MS, performed a simple operation to unblock restricted bloodflow out of the brain - and two years after the surgery, 73% of the patients had no symptoms. Dr. Zamboni's thinking could turn the current understanding of MS on its head, and offer many sufferers a complete cure.

Multiple sclerosis, or MS, has long been regarded as a life sentence of debilitating nerve degeneration. More common in females, the disease affects an estimated 2.5 million people around the world, causing physical and mental disabilities that can gradually destroy a patient's quality of life.

It's generally accepted that there's no cure for MS, only treatments that mitigate the symptoms - but a new way of looking at the disease has opened the door to a simple treatment that is causing radical improvements in a small sample of sufferers.

Italian Dr. Paolo Zamboni has put forward the idea that many types of MS are actually caused by a blockage of the pathways that remove excess iron from the brain - and by simply clearing out a couple of major veins to reopen the blood flow, the root cause of the disease can be eliminated.

Dr. Zamboni's revelations came as part of a very personal mission - to cure his wife as she began a downward spiral after diagnosis. Reading everything he could on the subject, Dr. Zamboni found a number of century-old sources citing excess iron as a possible cause of MS. It happened to dovetail with some research he had been doing previously on how a buildup of iron can damage blood vessels in the legs - could it be that a buildup of iron was somehow damaging blood vessels in the brain?

He immediately took to the ultrasound machine to see if the idea had any merit - and made a staggering discovery. More than 90% of people with MS have some sort of malformation or blockage in the veins that drain blood from the brain. Including, as it turned out, his wife.

He formed a hypothesis on how this could lead to MS: iron builds up in the brain, blocking and damaging these crucial blood vessels. As the vessels rupture, they allow both the iron itself, and immune cells from the bloodstream, to cross the blood-brain barrier into the cerebro-spinal fluid. Once the immune cells have direct access to the immune system, they begin to attack the myelin sheathing of the cerebral nerves - Multiple Sclerosis develops.

He named the problem Chronic Cerebro-Spinal Venous Insufficiency, or CCSVI.

Zamboni immediately scheduled his wife for a simple operation to unblock the veins - a catheter was threaded up through blood vessels in the groin area, all the way up to the effected area, and then a small balloon was inflated to clear out the blockage. It's a standard and relatively risk-free operation - and the results were immediate. In the three years since the surgery, Dr. Zamboni's wife has not had an attack.

Widening out his study, Dr. Zamboni then tried the same operation on a group of 65 MS-sufferers, identifying blood drainage blockages in the brain and unblocking them - and more than 73% of the patients are completely free of the symptoms of MS, two years after the operation.

In some cases, a balloon is not enough to fully open the vein channel, which collapses either as soon as the balloon is removed, or sometime later. In these cases, a metal stent can easily be used, which remains in place holding the vein open permanently.

Dr. Zamboni's lucky find is yet to be accepted by the medical community, which is traditionally slow to accept revolutionary ideas. Still, most agree that while further study needs to be undertaken before this is looked upon as a cure for MS, the results thus far have been very positive.

Naturally, support groups for MS sufferers are buzzing with the news that a simple operation could free patients from what they have always been told would be a lifelong affliction, and further studies are being undertaken by researchers around the world hoping to confirm the link between CCSVI and MS, and open the door for the treatment to become available for sufferers worldwide.

It's certainly a very exciting find for MS sufferers, as it represents a possible complete cure, as opposed to an ongoing treatment of symptoms. We wish Dr. Zamboni and the various teams looking further into this issue the best of luck.

non mi sembra che questo si possa definire "curare"

[AlexGatti]

Originariamente inviato da dantes76

non mi sembra che questo si possa definire "curare"

ah no? e come lo definisci "curare"?

[lowenz]

Non mi sembra che riguardi però tutti i casi di SM, quelli dove c'è un problema alla mielina mica possono essere risolti così

[bjt2]

L'hai letto tutto l'articolo?
Secondo Zamboni l'accumulo di ferro danneggia le vene, le cellule immunitarie riescono a passare nel CSF e attaccano la mielina... Qui sul mio PC ho risonanze di circa un migliaio di pazienti con MS e la maggior parte delle placche in effetti origina vicino ai ventricoli... Purtroppo le risonanze che ho a disposizione hanno spessore di 4 mm, quindi non so se riesco a vedere con certezza la restrizione nelle vene... Inoltre le sequenze acquisite non sono angiografiche... Ma posso provare... Proprio ieri stavo gioccherellando con Amide, un software open source di visioni di immagini DICOM e stavo ricostruendo in 3D una mia risonanza di prova di qualche settimana fa ed ero riuscito a vedere le vene...

Questo è un volontario sano:



E questo è un malato di MS in stadio molto avanzato:

[lowenz]

Originariamente inviato da bjt2

L'hai letto tutto l'articolo?
Secondo Zamboni l'accumulo di ferro danneggia le vene, le cellule immunitarie riescono a passare nel CSF e attaccano la mielina

He formed a hypothesis on how this could lead to MS: iron builds up in the brain, blocking and damaging these crucial blood vessels. As the vessels rupture, they allow both the iron itself, and immune cells from the bloodstream, to cross the blood-brain barrier into the cerebro-spinal fluid.

Ah ecco, quindi passerebbero in seguito a "microaneurismi".....beh allora sarebbe facile da vedere

[D1o]

La prima pubblicazione secondo wiki risale al 2006. Non conosco le tempistiche, ma quanto tempo è necessario per i trials per stabilire la bonta o meno delle sue ipotesi?

[bjt2]

Originariamente inviato da D1o

La prima pubblicazione secondo wiki risale al 2006. Non conosco le tempistiche, ma quanto tempo è necessario per i trials per stabilire la bonta o meno delle sue ipotesi?

Beh, in questo momento sto elaborando il follow up a due anni di un trial a doppio cieco su un farmaco sperimentale in aggiunta alla cura standard... Però non so come funziona nel caso di procedimenti chirurgici... Immagino si debba seguire i pazienti per tot anni e poi si può dare l'ok...

[frankytop]

Zamboni immediately scheduled his wife for a simple operation to unblock the veins - a catheter was threaded up through blood vessels in the groin area, all the way up to the effected area, and then a small balloon was inflated to clear out the blockage. It's a standard and relatively risk-free operation - and the results were immediate. In the three years since the surgery, Dr. Zamboni's wife has not had an attack.

Beh se per molti casi è sufficiente usare un palloncino non vedo perchè sia necessario aspettare anni per sperimentare e avallare questa pratica.

[Ziosilvio]

Purtroppo pare che cura ancora non sia
http://medbunker.blogspot.com/2010/0...a-la-cura.html

[AlexGatti]

Originariamente inviato da Ziosilvio

Purtroppo pare che cura ancora non sia
http://medbunker.blogspot.com/2010/0...a-la-cura.html

Effettivamente ci sono dei dubbi e gli studi dovranno essere prolungati. Ma questo è normale quando si ha a che fare con una malattia ad andamento intermittente. C'è sempre il dubbio che i miglioramenti siano casuali e non causati dalle cure sperimentali.

Speriamo che comunque venga dimostrato che questo trattamento porta benefici ai malati.

[criccu]

Originariamente inviato da dantes76

non mi sembra che questo si possa definire "curare"

dare immunosoppressori random invece è una cura

[Ziosilvio]

Originariamente inviato da criccu

dare immunosoppressori random invece è una cura

Somministrare immunosoppressori cercando quelli che funzionano bene, è una terapia.
E fornisce sollievo, e speranze, agli ammalati e alle loro famiglie molto più di quanto faccia qualsiasi "cura alternativa".
Evitiamo fantasie complottistiche. Anche solo per rispetto di queste persone.

[bjt2]

Non so se qualcuno ha linkato questo:

Intervento del Prof Salvetti su questo argomento del 28 novembre 2009:

Parte 1
Parte 2
Parte 3
Parte 4

E' spiegato in termini comprensibili anche ai profani...

Ho chiesto numi al mio collega neurologo e mi ha detto più o meno quello che è stato detto in questi video...

[lowenz]

Originariamente inviato da criccu

dare immunosoppressori random invece è una cura

E' una cura per ogni forma allergica.....o vuoi che il tuo bel sistema immunitario ti disintegri quando va fuori controllo?

[drakend]

Certo che le malattie autoimmuni sono paradossali... voglio dire il sistema immunitario dovrebbe proteggerci ed invece è quello che ci aggredisce...

[Ziosilvio]

Originariamente inviato da drakend

Certo che le malattie autoimmuni sono paradossali... voglio dire il sistema immunitario dovrebbe proteggerci ed invece è quello che ci aggredisce...

Beh, è come se l'antivirus avesse un falso positivo, e cancellasse dei file dei sistema

Piccola nota "informatico-filosofica":
Un teorema dovuto a Fred Cohen dice che, per ogni antivirus, esiste un programma su cui l'antivirus dà un risultato errato (falso positivo o falso negativo).
Forse anche il nostro "antivirus biologico" ha lo stesso problema...

Originariamente inviato da Ziosilvio

Somministrare immunosoppressori cercando quelli che funzionano bene, è una terapia.
E fornisce sollievo, e speranze, agli ammalati e alle loro famiglie molto più di quanto faccia qualsiasi "cura alternativa".
Evitiamo fantasie complottistiche. Anche solo per rispetto di queste persone.

Ho familiari con malattie autoimmuni che un tempo non sarebbero vissuti. Grazie agli immunosoppressori (che non vengono somministrati random) conducono una vita normale.

A chi mi dira' che un tempo non c'erano faccio notare che sto seguendo un documentario sulla vita di Meucci che aveva la moglie devastata dall'artrite reumatoide.

Il lupus era una condanna a morte mentre adesso non lo e' piu'.

Cura non significa sempre guarigione ma anche controllo della malattia.

[bjt2]

Ho parlato con il mio capo di questa cosa e ho scoperto che il nostro primario di ecografia (primo ricercatore dell'istituto del CNR in cui lavoro) era stato da Zamboni un mese fa per una settimana. Ora ho capito cos'è quel traffico di malati dalla risonanza all'ecografia. Proprio adesso (si: ora alle 10 di sera) sta facendo l'ecodoppler a due malati di sclerosi, di cui uno sulla sedia a rotelle, che si erano appena fatti la RM anche con contrasto (Gadolinio). Mi è stato detto che il prof di ecografia sta collaborando con Zamboni, quindi prevedo lavori in uscita...