Quote:
Originariamente inviato da Techie
https://www.medrxiv.org/content/10.1....06.21261707v2
Suppongo sia questo, adesso non ho tempo di leggerlo.
I dati sono da gennaio a luglio... se bastano 6-7 mesi per ridurre l'efficacia del vaccino Pfizer a quei livelli, non mi sembra tanto una buona notizia (anche se è per l'infezione non grave).
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"Several factors could contribute to the observed differences in effectiveness of mRNA-1273 and BNT162b2. Although both are nucleoside-modified mRNA vaccines encoding the prefusion stabilized SARS-CoV-2 Spike protein, there are differences in the vaccination regimen and formulation.18,19 BNT162b2 is administered as 30μg/0.3mL (100 μg/mL) doses 21 days apart20 and the Moderna vaccine is administered as 100μg/0.5mL (200 μg/mL) doses 28 days
apart.21"
"
Assuming similar sized constructs, this means that
each mRNA-1273 dose provides three times more mRNA copies of the Spike protein than BNT162b2, which could result in more effective priming of the immune response. There has not been a head-to-head comparison of the neutralizing antibody titers elicited by BNT162b2 versus mRNA-1273, but such a study could
provide important context for our results."
"Furthermore, there are differences in the lipid composition of the nanoparticles used for packaging the mRNA content of mRNA-1273 and BNT162b2."
Fonte: Estratto da 'Discussion' pag.10 di 'Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence'